Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513761 | 0.87 | PDE9A (0.49) | PDE9APDE1CKCNH2 | |
| SCHEMBL13865976 | 0.86 | PDE9A (0.50) | PDE9APDE1CKCNH2 | |
| SCHEMBL13870625 | 0.85 | PDE9A (0.46) | PDE9APDE1CKCNH2 | |
| SCHEMBL4510262 | 0.85 | PDE9A (0.51) | PDE9APDE1C | |
| SCHEMBL13865981 | 0.81 | PDE9A (0.49) | PDE9APDE1C | |
| SCHEMBL13865963 | 0.81 | PDE9A (0.50) | PDE9APDE1C | |
| SCHEMBL13865776 | 0.81 | PDE9A (0.58) | PDE9APDE1CKCNH2 | |
| SCHEMBL13865984 | 0.80 | PDE9A (0.49) | PDE9APDE1CKCNH2 | |
| SCHEMBL13866017 | 0.79 | PDE9A (0.59) | PDE9APDE1C | |
| SCHEMBL13865737 | 0.79 | PDE9A (0.54) | PDE9APDE1CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | PDE4A, PDE7B, PDE4B | PDE9A 13/4885PDE1C 190/4885KCNH2 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.