Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103018 | 0.89 | HTT (0.51) | SMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL4102925 | 0.86 | FES (0.52) | KDM4ESMN1; SMN2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL4113322 | 0.84 | BACE1 (0.44) | KDM4ETP53ALDH1A1KMT2AHPGD | |
| SCHEMBL4108478 | 0.82 | CA12 (0.52) | HSD17B10ALDH1A1CA12CA1CA2 | |
| SCHEMBL4097578 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4096892 | 0.77 | KMT2A (0.49) | KDM4EHSD17B10ALDH1A1POLBCA12 | |
| SCHEMBL4106629 | 0.77 | CA12 (0.52) | KDM4ESMN1; SMN2EPHX1TP53EPHX2 | |
| SCHEMBL27312078 | 0.76 | ASAH1 (0.57) | KDM4ESMN1; SMN2HSD17B10ALDH1A1POLB | |
| SCHEMBL16728178 | 0.75 | EPHX1 (0.47) | KDM4ESMN1; SMN2EPHX1TP53ALDH1A1 | |
| SCHEMBL714625 | 0.73 | EPHX1 (0.77) | KDM4EGSK3BSMN1; SMN2EPHX1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106753-A1 | NOVEL DERIVATIVES OF 1H-INDOL-1-YL UREA, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-09-03 | — | — | WO | disclosed |
| EP-2078716-A1 | New derivatives of 1H-indol-1-yl-urea, method for preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-07-15 | — | — | EP | disclosed |