Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.59 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755933 | 0.92 | ACVR2A (0.61) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL6755939 | 0.92 | ACVR2A (0.61) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL6174452 | 0.92 | ACVR2A (0.61) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL6755936 | 0.92 | ACVR2A (0.61) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL410791 | 0.92 | ACVR2A (0.61) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL413792 | 0.83 | ACVR2A (0.70) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL413844 | 0.83 | ACVR2A (0.60) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL413370 | 0.82 | ACVR2A (0.67) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL410503 | 0.81 | ACVR2A (0.68) | ACVR2ATGFBR2KDRPLK4AURKA | |
| SCHEMBL409369 | 0.79 | ACVR2A (0.57) | ACVR2ATGFBR2KDRPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140120621-A1 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8298825-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |