Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.42 |
| ▸ | NEK4 | P51957 | 3/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513046 | 1.00 | AKT1 (0.56) | AKT1KMT2AAKT3AKT2GSK3B | |
| SCHEMBL4513055 | 1.00 | AKT1 (0.56) | AKT1KMT2AAKT3AKT2GSK3B | |
| Hydrochloric Acid SCHEMBL4349100 | 0.87 | AKT1 (0.45) | AKT1KMT2AAKT3GSK3BRPS6KA5 | |
| Hydrochloric Acid SCHEMBL4349093 | 0.87 | AKT1 (0.45) | AKT1KMT2AAKT3GSK3BRPS6KA5 | |
| SCHEMBL4346678 | 0.86 | AKT1 (0.44) | AKT1KMT2AGSK3BRPS6KB1JAK3 | |
| SCHEMBL4354582 | 0.85 | KMT2A (0.50) | AKT1KMT2AGSK3BCHEK1CDK9 | |
| SCHEMBL4343997 | 0.85 | KMT2A (0.50) | AKT1KMT2AGSK3BCHEK1CDK9 | |
| SCHEMBL4355953 | 0.84 | DYRK1A (0.44) | AKT1KMT2AAKT3GSK3BRPS6KA5 | |
| SCHEMBL13821642 | 0.84 | AKT1 (0.41) | AKT1KMT2AAKT3GSK3BRPS6KA5 | |
| SCHEMBL4349063 | 0.84 | DYRK1A (0.44) | AKT1KMT2AAKT3GSK3BRPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |