SCHEMBL4513694

SCHEMBL4513694

CCOC(=O)C(C)(C)Oc1ccc(C(=O)CCc2sc(-c3ccc(C(F)(F)F)cc3)nc2CN2CCN(Cc3ccc(OC)cc3)CC2)cc1C

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 12/20 0.45
PPARA Q07869 11/20 0.45
PPARG P37231 5/20 0.42
STAT3 P40763 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
PRKAB2 O43741 1/20 0.40
PRKAG1 P54619 1/20 0.40
PRKAA2 P54646 1/20 0.40
PRKAA1 Q13131 1/20 0.40
PRKAG3 Q9UGI9 1/20 0.40
PRKAG2 Q9UGJ0 1/20 0.40
PRKAB1 Q9Y478 1/20 0.40
MAPT P10636 1/20 0.39
ACHE P22303 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4503622 0.95 PPARD (0.49) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4508575 0.94 MAPT (0.44) PPARDPPARAPPARGSTAT3MEN1
SCHEMBL4524154 0.93 PPARA (0.54) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4520214 0.91 PPARD (0.52) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4514629 0.91 PPARD (0.44) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4515550 0.90 PPARD (0.48) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4515584 0.90 PPARD (0.48) PPARDPPARAPPARG
SCHEMBL4507824 0.90 PPARD (0.47) PPARDPPARAPPARGMAPT
SCHEMBL4500419 0.90 PPARD (0.50) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL4524332 0.89 PPARD (0.42) PPARDPPARAPPARGKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor NIPPON CHEMIPHAR CO., LTD. (JP) 2009-08-13 US disclosed
EP-1897872-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2008-03-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203908-A1 Activator for Peroxisome Proliferator-Activated Receptor PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.