SCHEMBL451458

SCHEMBL451458

CC(C)(C)C=C(C#N)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EGFR P00533 4/20 0.38
KDM4E B2RXH2 3/20 0.38
CISD1 Q9NZ45 1/20 0.38
SLC16A3 O15427 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP3A4 P08684 1/20 0.38
HPGD P15428 1/20 0.38
SLC16A1 P53985 1/20 0.38
GPR35 Q9HC97 1/20 0.38
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.36
KMT2A Q03164 1/20 0.36
GRIK1 P39086 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13206629 1.00 EGFR (0.38) EGFRKDM4ECISD1SLC16A3ALDH1A1
SCHEMBL30682963 1.00 EGFR (0.38) EGFRKDM4ECISD1SLC16A3ALDH1A1
SCHEMBL30682965 1.00 EGFR (0.38) EGFRKDM4ECISD1SLC16A3ALDH1A1
SCHEMBL18959027 0.81 MEN1 (0.34) EGFRALDH1A1KMT2A
SCHEMBL15710434 0.79 EGFR (0.45) EGFRKDM4EALDH1A1CYP3A4HPGD
SCHEMBL19421178 0.79 MEN1 (0.49) EGFRALDH1A1KMT2A
SCHEMBL13857847 0.79 MEN1 (0.33) EGFRALDH1A1KMT2A
SCHEMBL13857846 0.79 MEN1 (0.33) EGFRALDH1A1KMT2A
SCHEMBL15710430 0.79 EGFR (0.45) EGFRKDM4EALDH1A1CYP3A4HPGD
SCHEMBL32684869 0.77 KDM4E (0.33) EGFRKDM4ECISD1SLC16A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9752049-B2 Optically transparent, superhydrophobic, biocompatible thin film coatings and methods for producing same UT-BATTELLE, LLC (US) 2017-09-05 US claimed
US-20150232690-A1 OPTICALLY TRANSPARENT, SUPERHYDROPHOBIC, BIOCOMPATIBLE THIN FILM COATINGS AND METHODS FOR PRODUCING SAME UT-BATTELLE, LLC (US) 2015-08-20 US claimed
EP-1100380-B1 BIOABSORBABLE BLENDS AND SURGICAL ARTICLES THEREFROM TYCO HEALTHCARE (US) 2011-11-02 EP claimed
EP-1455738-B1 USE OF ELECTROPHILIC MONOMERS FOR HAIR TREATMENT OREAL (FR) 2010-07-28 EP claimed
EP-1360257-B1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS LOCTITE R & D LTD (IE) 2007-07-25 EP claimed
US-6977278-B1 Cyanoacrylate compositions curable to flexible polymeric materials LOCTITE (R&D) LTD. (IE) 2005-12-20 US claimed
WO-2004024467-A2 SURFACE-MOUNTING SYSTEM LOCTITE (R & D) LIMITED (IE) 2004-03-25 WO claimed
EP-1360257-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS Loctite (R & D) Limited (IE) 2003-11-12 EP claimed
WO-2002053666-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS LOCTITE (R & D) LIMITED (IE) 2002-07-11 WO claimed
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LTD (GB) 2026-04-02 US disclosed
EP-3710458-B1 IMMUNOPROTEASOME INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2026-03-25 EP disclosed
EP-3912979-B1 TYROSINE KINASE INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2026-03-25 EP disclosed
US-20260022123-A1 Methods of Making Modified BTK Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2026-01-22 US disclosed
EP-3181567-B9 PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2025-09-24 EP disclosed
WO-2007054113-A1 ADHESIVES, SEALANTS AND COATINGS CONTAINING GLASS PARTICLES AS A FILLER HENKEL AG & CO. KGAA (DE) 2007-05-18 WO disclosed
US-6977278-B1 Cyanoacrylate compositions curable to flexible polymeric materials LOCTITE (R&D) LTD. (IE) 2005-12-20 US disclosed
WO-2004024467-A2 SURFACE-MOUNTING SYSTEM LOCTITE (R & D) LIMITED (IE) 2004-03-25 WO disclosed
EP-1360257-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS Loctite (R & D) Limited (IE) 2003-11-12 EP disclosed
WO-2002053666-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS LOCTITE (R & D) LIMITED (IE) 2002-07-11 WO disclosed
WO-1999023150-A1 CYANOACRYLATE POLYMER COMPOSITIONS COMPRISING AN ANTIMICROBIAL AGENT MEDLOGIC GLOBAL CORPORATION (US) 1999-05-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022123-A1 Methods of Making Modified BTK Inhibitors BTK, TEC, SYK EGFR 637/4885KDM4E 287/4885CISD1 2096/4885
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BCL9L, RBBP9, BRD9 EGFR 633/4885KDM4E 3785/4885CISD1 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.