Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.34 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511202 | 0.98 | HRH3 (0.39) | SMYD3HRH3SMN1; SMN2ALOX15IKBKB | |
| SCHEMBL4504695 | 0.90 | PARP1 (0.38) | SMYD3HRH3SMN1; SMN2ALOX15LOX | |
| SCHEMBL4354178 | 0.76 | SMYD3 (0.41) | SMYD3HRH3SMN1; SMN2ALOX15IKBKB | |
| SCHEMBL4202177 | 0.75 | HRH3 (0.42) | SMYD3HRH3SMN1; SMN2ALOX15IKBKB | |
| SCHEMBL4500677 | 0.74 | HRH3 (0.31) | HRH3 | |
| SCHEMBL4343696 | 0.73 | SMYD3 (0.37) | SMYD3HRH3SMN1; SMN2ALOX15IKBKB | |
| SCHEMBL4207692 | 0.72 | SMYD3 (0.39) | SMYD3HRH3SMN1; SMN2ALOX15IKBKB | |
| SCHEMBL4511299 | 0.71 | IKBKB (0.33) | SMYD3IKBKB | |
| SCHEMBL4506004 | 0.69 | HRH3 (0.31) | HRH3 | |
| Hydrochloric Acid SCHEMBL6619251 | 0.67 | HRH3 (0.50) | HRH3SMN1; SMN2LOXKCNH2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | CCNI, MKI67, CDK2 | SMYD3 4052/4885HRH3 3450/4885SMN1; SMN2 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.