Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.55 |
| ▸ | BACE1 | P56817 | 7/20 | 0.55 |
| ▸ | CDK2 | P24941 | 6/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518313 | 0.91 | CDK2 (0.52) | ACHEBACE1CDK2CDK4CDK1 | |
| SCHEMBL4200806 | 0.85 | CDK2 (0.54) | CDK2CDK4CDK1KCNH2 | |
| SCHEMBL4504031 | 0.84 | CDK2 (0.66) | CDK2CDK4CDK1KCNH2MAPK10 | |
| SCHEMBL4517599 | 0.84 | CDK2 (0.56) | CDK2CDK4CDK1KCNH2 | |
| SCHEMBL4199373 | 0.83 | CDK2 (0.52) | ACHEBACE1CDK2CDK1KCNH2 | |
| SCHEMBL4193060 | 0.83 | CDK2 (0.53) | CDK2CDK4CDK1KCNH2MAPK10 | |
| SCHEMBL4200743 | 0.82 | CDK2 (0.62) | CDK2CDK4CDK1KCNH2MAPK10 | |
| SCHEMBL4509075 | 0.81 | CDK2 (0.61) | CDK2CDK4CDK1KCNH2 | |
| SCHEMBL4516072 | 0.80 | CDK2 (0.62) | CDK2CDK4CDK1KCNH2MAPK10 | |
| SCHEMBL3221422 | 0.80 | CDK2 (0.58) | CDK2CDK4CDK1KCNH2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275567-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | CCNI, MKI67, CDK2 | ACHE 4677/4885BACE1 4490/4885CDK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.