SCHEMBL451670

SCHEMBL451670

N#Cc1cc(O)ccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3881495 0.78 MYC (0.64)
SCHEMBL7475752 0.77
SCHEMBL9792895 0.76 MYC (0.62)
SCHEMBL31133396 0.76 MYC (0.62)
SCHEMBL1145922 0.74
SCHEMBL995799 0.74 CLK4 (0.44)
SCHEMBL29598148 0.74 CLK4 (0.44)
SCHEMBL131627 0.74
SCHEMBL24605595 0.73
SCHEMBL91455 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
US-20260035375-A1 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2026-02-05 US disclosed
US-12509460-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2025-12-30 US disclosed
US-12459952-B2 TREM2 modulators MUNA THERAPEUTICS APS (DK) 2025-11-04 US disclosed
US-20250275959-A1 COMPOUNDS AND METHODS OF THEIR USE LEXICON PHARMACEUTICALS, INC. 2025-09-04 US disclosed
US-20250223293-A1 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2025-07-10 US disclosed
US-20250197420-A1 MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2025-06-19 US disclosed
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2025-04-17 US disclosed
EP-4417607-A1 HETEROCYCLIC COMPOUND AS SOS1 INHIBITOR AND USES THEREOF Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) 2024-08-21 EP disclosed
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-23 US disclosed
US-20050070712-A1 Pyrimidine derivatives as ghrelin receptor modulators ABBOTT LABORATORIES 2005-03-31 US disclosed
US-6864270-B2 Iron binding agents UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2005-03-08 US disclosed
US-20050009843-A1 Medicine for inhibiting drug elimination pump TRINE PHARMACEUTICALS, INC. 2005-01-13 US disclosed
EP-1488791-A2 Antimalarial agents UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2004-12-22 EP disclosed
EP-1389463-A1 MEDICINE FOR INHIBITING DRUG ELIMINATION PUMP DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-02-18 EP disclosed
US-20030092720-A1 Drug efflux pump inhibitor DAIICHI PHARMACEUTICAL CO., LTD (JP) 2003-05-15 US disclosed
US-20030083349-A1 Iron binding agents UNIVERSITY OF FLORIDA (US) 2003-05-01 US disclosed
EP-1143951-A2 ANTIMALARIAL AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2001-10-17 EP disclosed
WO-2000016763-A2 ANTIMALARIAL AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2000-03-30 WO disclosed
US-4046896-A 1-Methyl-2-(pyridyl-oxymethyl)-5-nitro-imidazoles HOECHST AKTIENGESELLSCHAFT (DT) 1977-09-06 US disclosed