SCHEMBL4516889

SCHEMBL4516889

Cc1c(C(=O)NN2CCCCCC2)nc(-c2ccc(Cl)cc2Cl)n1-c1cc(Cl)ccn1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 0.79
CNR2 P34972 16/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4508501 1.00 CNR1 (0.79) CNR1CNR2
SCHEMBL674905 0.91 CNR1 (0.80) CNR1CNR2
SCHEMBL4506565 0.91 CNR1 (0.76) CNR1CNR2
SCHEMBL4497043 0.89 CNR1 (0.77) CNR1CNR2
SCHEMBL4510012 0.89 CNR1 (0.77) CNR1CNR2
SCHEMBL6104725 0.89 CNR1 (1.00) CNR1CNR2
SCHEMBL6104428 0.89 CNR1 (1.00) CNR1CNR2
SCHEMBL6879980 0.87 CNR1 (0.73) CNR1CNR2
SCHEMBL4511060 0.86 CNR1 (1.00) CNR1CNR2
SCHEMBL675659 0.86 CNR1 (1.00) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8729101-B2 1H-imidazole derivative having CB1, agonistic, CB1 partial agonistic or CB1 antagnistic activity SOLVAY PHARMACEUTICALS, B.V. (NL) 2014-05-20 US claimed
EP-1438296-B1 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY SOLVAY PHARM BV (NL) 2008-11-26 EP claimed
US-11059779-B2 Storage stable aqueous organic peroxide emulsions NOURYON CHEMICALS INTERNATIONAL B.V. (NL) 2021-07-13 US disclosed
EP-3429991-B1 STORAGE STABLE AQUEOUS ORGANIC PEROXIDE EMULSIONS NOURYON CHEMICALS INT BV (NL) 2020-05-06 EP disclosed
US-20190071397-A1 STORAGE STABLE AQUEOUS ORGANIC PEROXIDE EMULSIONS NOURYON CHEMICALS INTERNATIONAL B.V. (NL) 2019-03-07 US disclosed
EP-1373198-B2 STORAGE STABLE AQUEOUS ORGANIC PEROXIDE EMULSIONS AKZO NOBEL NV (NL) 2015-02-25 EP disclosed
US-8729101-B2 1H-imidazole derivative having CB1, agonistic, CB1 partial agonistic or CB1 antagnistic activity SOLVAY PHARMACEUTICALS, B.V. (NL) 2014-05-20 US disclosed
US-20090181949-A1 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY SOLVAY PHARMACEUTICALS B.V. 2009-07-16 US disclosed
EP-1438296-B1 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY SOLVAY PHARM BV (NL) 2008-11-26 EP disclosed
EP-1373198-B1 STORAGE STABLE AQUEOUS ORGANIC PEROXIDE EMULSIONS AKZO NOBEL NV (NL) 2008-04-23 EP disclosed
US-7214329-B2 For use in polymerization of vinyl chloride monomer AKZO NOBEL N.V. (NL) 2007-05-08 US disclosed
US-20040235854-A1 1H-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1 antagonistic activity SOLVAY PHARMACEUTICALS B.V. (NL) 2004-11-25 US disclosed
EP-1438296-A2 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY Solvay Pharmaceuticals B.V. (NL) 2004-07-21 EP disclosed
US-20040132938-A1 For use in polymerization of vinyl chloride monomer WILMINGTON TRUST (LONDON) LIMITED, AS COLLATERAL AGENT (GB) 2004-07-08 US disclosed
WO-2003027076-A2 1H-IMIDAZOLE DERIVATIVES HAVING CB1 AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1- ANTAGONISTIC ACTIVITY SOLVAY PHARMACEUTICALS B.V. (NL) 2003-04-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181949-A1 1H-IMIDAZOLE DERIVATIVE HAVING CB1, AGONISTIC, CB1 PARTIAL AGONISTIC OR CB1 ANTAGNISTIC ACTIVITY CNR1, CNR2, CHRM1 CNR1 1/4885CNR2 2/4885
US-20040235854-A1 1H-imidazole derivatives having cb1 agonistic, cb1 partial agonistic or cb1 antagonistic activity CNR1, CNR2, CHRM1 CNR1 1/4885CNR2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.