Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.31 |
| ▸ | GSK3A | P49840 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517463 | 1.00 | GSK3B (0.31) | GSK3BGSK3AKDM4EGAAHPGD | |
| SCHEMBL4497886 | 0.86 | SMPD2 (0.32) | GSK3BGSK3A | |
| SCHEMBL4497882 | 0.86 | SMPD2 (0.32) | GSK3BGSK3A | |
| SCHEMBL4508771 | 0.79 | GSK3B (0.36) | GSK3BGSK3A | |
| SCHEMBL4508767 | 0.79 | GSK3B (0.36) | GSK3BGSK3A | |
| SCHEMBL4513957 | 0.79 | GSK3B (0.34) | GSK3BGSK3AKDM4EGAAHPGD | |
| SCHEMBL4244551 | 0.69 | GSK3B (0.34) | GSK3BGSK3A | |
| SCHEMBL4244547 | 0.69 | GSK3B (0.34) | GSK3BGSK3A | |
| SCHEMBL4493782 | 0.67 | GSK3B (0.39) | GSK3BGSK3A | |
| SCHEMBL4495652 | 0.66 | GSK3A (0.38) | GSK3BGSK3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501435-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070254879-A1 | Inhibitors of checkpoint kinases | MERCK SHARP & DOHME CORP. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254879-A1 | Inhibitors of checkpoint kinases | CHEK1, CHEK2, PLK1 | GSK3B 199/4885GSK3A 226/4885KDM4E 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.