Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781652 | 0.87 | DPP4 (0.43) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL23087911 | 0.86 | AKR1C3 (0.40) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL28218518 | 0.84 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL27214493 | 0.81 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL4827833 | 0.79 | AKR1C2 (0.64) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL31424007 | 0.78 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL8467899 | 0.78 | AKR1C4 (0.63) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL29684531 | 0.78 | AKR1C4 (0.63) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL1571554 | 0.78 | KDM4E (0.50) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 | |
| SCHEMBL22492250 | 0.78 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1C1AKR1C4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118451068-A | Tri-fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| US-11920040-B2 | Carborhodamine compounds and methods of preparation thereof | ELITECHGROUP MDX LLC (US) | 2024-03-05 | — | — | US | disclosed |
| US-20230105320-A1 | CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF | ELITECHGROUP MDX LLC (US) | 2023-04-06 | — | — | US | disclosed |
| US-20230105320-A1 | CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF | ELITECHGROUP MDX LLC (US) | 2023-04-06 | — | — | US | disclosed |
| US-11618826-B2 | Carborhodamine compounds and methods of preparation thereof | ELITECHGROUP MDX LLC (US) | 2023-04-04 | — | — | US | disclosed |
| WO-2022246179-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
| US-20220002549-A1 | CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF | ELITECHGROUP, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-20220002549-A1 | CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF | ELITECHGROUP, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11155713-B2 | Carborhodamine compounds and methods of preparation thereof | ELITECHGROUP, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-11155713-B2 | Carborhodamine compounds and methods of preparation thereof | ELITECHGROUP, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| EP-3802526-A1 | CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF | ELITechGroup, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |
| US-20090298894-A1 | AMINO ACID COMPOUNDS | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | AXL, BTK, MERTK | AKR1C3 3845/4885AKR1C2 3858/4885AKR1C1 3873/4885 |
| US-20090298894-A1 | AMINO ACID COMPOUNDS | S1PR1, S1PR2, S1PR5 | AKR1C3 1902/4885AKR1C2 2495/4885AKR1C1 2041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.