Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | CTSD | P07339 | 9/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514245 | 0.88 | BACE1 (0.78) | BACE1CTSDBACE2REN | |
| SCHEMBL4521613 | 0.86 | BACE1 (0.77) | BACE1CTSDBACE2REN | |
| SCHEMBL4509526 | 0.85 | BACE1 (0.69) | BACE1CTSDBACE2REN | |
| SCHEMBL4513073 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL4516116 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL4516333 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL4516633 | 0.82 | BACE1 (0.77) | BACE1CTSDBACE2 | |
| SCHEMBL4507469 | 0.81 | BACE1 (0.73) | BACE1CTSD | |
| SCHEMBL4501686 | 0.81 | BACE1 (0.82) | BACE1CTSDBACE2REN | |
| SCHEMBL4501534 | 0.79 | BACE1 (0.72) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582667-B2 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2009-09-01 | — | — | US | claimed |
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2007-08-30 | — | — | US | claimed |
| US-7582667-B2 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | BACE1, BACE2, APP | BACE1 1/4885CTSD 119/4885BACE2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.