Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 17/20 | 0.47 |
| ▸ | WNT1 | P04628 | 12/20 | 0.47 |
| ▸ | CLK2 | P49760 | 7/20 | 0.46 |
| ▸ | CLK3 | P49761 | 7/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951209 | 0.92 | DYRK1A (0.54) | DYRK1AWNT1CLK2CLK3PIK3C3 | |
| SCHEMBL81513 | 0.88 | DYRK1A (0.56) | DYRK1AWNT1CLK2CLK3LRRK2 | |
| SCHEMBL6221809 | 0.85 | DYRK1A (0.50) | DYRK1AWNT1CLK2CLK3PIK3C3 | |
| SCHEMBL81169 | 0.79 | DYRK1A (0.45) | DYRK1AWNT1CLK2CLK3PIK3C3 | |
| SCHEMBL82655 | 0.77 | DYRK1A (0.70) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL5716625 | 0.77 | DYRK1A (0.56) | DYRK1AWNT1CLK2CLK3LRRK2 | |
| Hydrochloric Acid SCHEMBL951130 | 0.76 | DYRK1A (0.55) | DYRK1AWNT1CLK2CLK3LRRK2 | |
| Hydrochloric Acid SCHEMBL4529550 | 0.76 | DYRK1A (0.55) | DYRK1AWNT1CLK2CLK3LRRK2 | |
| SCHEMBL955157 | 0.75 | DYRK1A (0.54) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL5916060 | 0.74 | DYRK1A (0.59) | DYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | claimed |