Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45213 | 0.92 | SLC34A2 (0.48) | BRAFRAF1SLC34A2POLBHPGD | |
| SCHEMBL18471336 | 0.91 | SLC34A2 (0.49) | BRAFRAF1SLC34A2POLBHPGD | |
| SCHEMBL46746 | 0.86 | SLC34A2 (0.47) | BRAFRAF1SLC34A2KDM4EALDH1A1 | |
| SCHEMBL15420846 | 0.85 | SLC34A2 (0.48) | BRAFRAF1SLC34A2KDM4EALDH1A1 | |
| SCHEMBL19595916 | 0.84 | BRAF (0.48) | BRAFRAF1SLC34A2KDM4EROCK2 | |
| SCHEMBL18482281 | 0.84 | SLC34A2 (0.48) | BRAFRAF1SLC34A2POLBHPGD | |
| SCHEMBL15432502 | 0.83 | SLC34A2 (0.52) | BRAFRAF1SLC34A2KDM4EROCK2 | |
| SCHEMBL46720 | 0.83 | SLC34A2 (0.42) | BRAFRAF1SLC34A2KDM4EALDH1A1 | |
| SCHEMBL46687 | 0.82 | SLC34A2 (0.48) | BRAFRAF1SLC34A2POLBHPGD | |
| SCHEMBL46684 | 0.82 | SLC34A2 (0.47) | BRAFRAF1SLC34A2POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |