Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 15/20 | 0.61 |
| ▸ | PPARD | Q03181 | 15/20 | 0.61 |
| ▸ | PPARG | P37231 | 9/20 | 0.61 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523580 | 0.97 | PPARA (0.61) | PPARAPPARDPPARGMOGAT2FFAR1 | |
| SCHEMBL12150583 | 0.95 | PPARA (0.63) | PPARAPPARDPPARGMOGAT2FFAR1 | |
| SCHEMBL4519221 | 0.91 | PPARA (0.51) | PPARAPPARDPPARGMOGAT2 | |
| SCHEMBL13334167 | 0.90 | PPARA (0.56) | PPARAPPARDPPARGMOGAT2 | |
| SCHEMBL13334366 | 0.86 | PPARD (0.51) | PPARAPPARDPPARGMOGAT2FFAR1 | |
| SCHEMBL4510079 | 0.84 | PPARA (0.59) | PPARAPPARDPPARGFFAR1 | |
| SCHEMBL4518782 | 0.84 | PPARA (0.59) | PPARAPPARDPPARGFFAR1 | |
| SCHEMBL4867536 | 0.83 | PPARA (0.58) | PPARAPPARDPPARG | |
| SCHEMBL12151188 | 0.83 | PPARD (0.60) | PPARAPPARDPPARGFFAR1 | |
| SCHEMBL5476557 | 0.82 | PPARA (0.65) | PPARAPPARDPPARGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | IRM LLC (BM) | 2009-01-08 | — | — | US | claimed |
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | IRM LLC (BM) | 2009-01-08 | — | — | US | disclosed |
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | IRM LLC (BM) | 2009-01-08 | — | — | US | disclosed |
| EP-1979347-A2 | POLYCYCLIC 1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089557-A2 | POLYCYCLIC 1, 2, 3, 4 -TETRAHYDRO- ISOQUINOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | PPARG, PPARD, PPARA | PPARA 3/4885PPARD 2/4885PPARG 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.