Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532643 | 0.89 | PDE4B (0.38) | PDE4BMEN1KMT2ACHRM5CHRM1 | |
| SCHEMBL4522549 | 0.86 | PDE4B (0.39) | PDE4BCHRM5CHRM1CHRM3PDE4A | |
| SCHEMBL5357326 | 0.84 | PDE4B (0.50) | PDE4BMEN1KMT2ACHRM5CHRM1 | |
| SCHEMBL5357323 | 0.84 | PDE4B (0.50) | PDE4BMEN1KMT2ACHRM5CHRM1 | |
| SCHEMBL4526027 | 0.84 | PDE4B (0.50) | PDE4BMEN1KMT2ACHRM5CHRM1 | |
| SCHEMBL4533075 | 0.82 | PDE4B (0.42) | PDE4B | |
| SCHEMBL4531608 | 0.81 | PDE4B (0.51) | PDE4BCHRM5CHRM1CHRM3PDE4A | |
| SCHEMBL4531612 | 0.81 | PDE4B (0.51) | PDE4BCHRM5CHRM1CHRM3PDE4A | |
| SCHEMBL4535539 | 0.81 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5350791 | 0.81 | PDE4B (0.51) | PDE4BCHRM5CHRM1CHRM3PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4294903-B2 | — | — | 2009-07-15 | — | — | JP | claimed |
| JP-2003519135-A | — | — | 2003-06-17 | — | — | JP | claimed |
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |