Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512733 | 0.91 | PIK3CA (0.43) | ALDH1A1PIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL4509798 | 0.84 | PIK3CA (0.48) | ALDH1A1KDM4EPIK3CGPIK3CAPIK3CD | |
| SCHEMBL4517148 | 0.81 | PIK3CA (0.46) | ALDH1A1KDM4EPIK3CGPIK3CAPIK3CD | |
| SCHEMBL4527351 | 0.80 | PIK3CD (0.67) | PIK3CGPIK3CAPIK3CDPIK3CBAKT1 | |
| SCHEMBL926624 | 0.80 | PIK3CD (0.60) | ALDH1A1KDM4EPIK3CGPIK3CAPIK3CD | |
| SCHEMBL4523490 | 0.74 | PIK3CD (0.50) | PIK3CGPIK3CAPIK3CDPIK3CBAKT1 | |
| SCHEMBL4523499 | 0.72 | PIK3CD (0.46) | PIK3CGPIK3CAPIK3CDPIK3CBKMT2A | |
| SCHEMBL4512724 | 0.71 | PIK3CD (0.68) | PIK3CGPIK3CAPIK3CDPIK3CBAKT1 | |
| SCHEMBL14735820 | 0.71 | AKT1 (0.65) | PIK3CGPIK3CAPIK3CDPIK3CBAKT1 | |
| SCHEMBL924648 | 0.70 | PIK3CD (0.51) | ALDH1A1KDM4EPIK3CGPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | MTOR, RPTOR, JAK2 | ALDH1A1 1838/4885KDM4E 2921/4885PIK3CG 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.