Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 17/20 | 0.58 |
| ▸ | CHRM2 known ✓ | P08172 | 11/20 | 0.58 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.58 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.58 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4513565 | 1.00 | CHRM3 (0.58) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4525650 | 0.96 | CHRM3 (0.52) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4523696 | 0.92 | CHRM3 (0.58) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4534435 | 0.92 | CHRM3 (0.58) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4534612 | 0.92 | CHRM3 (0.58) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL5478817 | 0.91 | CHRM3 (0.57) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4510354 | 0.91 | CHRM3 (0.57) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4560072 | 0.89 | CHRM3 (0.51) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4528532 | 0.89 | CHRM3 (0.51) | CHRM3CHRM2CHRM1KCNH2CHRM4 | |
| Bromide SCHEMBL4526614 | 0.88 | CHRM3 (0.50) | CHRM3CHRM2CHRM1KCNH2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504432-B2 | Ester derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |
| US-20070129397-A1 | Ester derivatives | MSD K.K. (JP) | 2007-06-07 | — | — | US | disclosed |
| US-7192969-B2 | Ester derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-03-20 | — | — | US | disclosed |
| US-20050065211-A1 | Ester derivatives | MSD K.K. (JP) | 2005-03-24 | — | — | US | disclosed |
| US-6846835-B2 | Treating chronic obstructive pulmonary disease, chronic bronchitis, asthma, chronic respiratory tract obstruction, fibroid lung, pulmonary emphysema or rhinitis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-01-25 | — | — | US | disclosed |
| US-20030191316-A1 | Ester derivatives | MSD K.K. (JP) | 2003-10-09 | — | — | US | disclosed |
| EP-1302458-A1 | ESTER DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2003-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129397-A1 | Ester derivatives | CHRM3, CHRM2, CHRM1 | CHRM3 1/4885CHRM2 2/4885CHRM1 3/4885 |
| US-20030191316-A1 | Ester derivatives | CHRM3, CHRM2, CHRM1 | CHRM3 1/4885CHRM2 2/4885CHRM1 3/4885 |
| US-20050065211-A1 | Ester derivatives | CHRM3, CHRM2, CHRM1 | CHRM3 1/4885CHRM2 2/4885CHRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.