Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.54 |
| ▸ | PAK4 | O96013 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528817 | 1.00 | PAK1 (0.54) | PAK1PAK4GSK3BDYRK3JAK2 | |
| SCHEMBL4526745 | 1.00 | PAK1 (0.54) | PAK1PAK4GSK3BDYRK3JAK2 | |
| Hydrochloric Acid SCHEMBL4527611 | 0.99 | PAK1 (0.53) | PAK1PAK4GSK3BDYRK3JAK2 | |
| Hydrochloric Acid SCHEMBL4527604 | 0.99 | PAK1 (0.53) | PAK1PAK4GSK3BDYRK3JAK2 | |
| SCHEMBL13633932 | 0.85 | IRAK4 (0.40) | PAK1PAK4GSK3BDYRK3JAK2 | |
| SCHEMBL4526261 | 0.85 | IRAK4 (0.40) | PAK1PAK4GSK3BDYRK3JAK2 | |
| SCHEMBL13633951 | 0.85 | IRAK4 (0.40) | PAK1PAK4GSK3BDYRK3JAK2 | |
| Hydrochloric Acid SCHEMBL4526304 | 0.84 | IRAK4 (0.40) | PAK1PAK4GSK3BDYRK3JAK2 | |
| Hydrochloric Acid SCHEMBL4526299 | 0.84 | IRAK4 (0.40) | PAK1PAK4GSK3BDYRK3JAK2 | |
| SCHEMBL22054603 | 0.81 | PAK1 (0.60) | PAK1PAK4GSK3BDYRK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281073-A1 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | BHATTACHARYA SAMIT KUMAR | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281073-A1 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNY, TP53, CCNE1 | PAK1 2492/4885PAK4 3321/4885GSK3B 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.