SCHEMBL4530973

SCHEMBL4530973

CC[C@@H](NC(=O)c1ccc(NCc2ccccn2)c([N+](=O)[O-])c1)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.54
MAPT P10636 9/20 0.51
MAPK1 P28482 3/20 0.49
ALDH1A1 P00352 1/20 0.47
CTSB P07858 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
HCAR3 P49019 1/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
ATM Q13315 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
PKM P14618 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8035877 0.88 PPARG (0.56) PPARGMAPTMAPK1RXFP1MEN1
SCHEMBL4540776 0.86 MAPT (0.63) MAPTMAPK1RXFP1HCAR3MEN1
SCHEMBL8041848 0.86 MAPT (0.56) PPARGMAPTMAPK1RXFP1HCAR3
SCHEMBL4542097 0.86 PPARG (0.56) PPARGMAPTMAPK1ALDH1A1RXFP1
SCHEMBL8033200 0.85 KCNK3 (0.47) MAPTMAPK1ALDH1A1RXFP1HCAR3
SCHEMBL4537201 0.85 PPARG (0.57) PPARGMAPTMAPK1ALDH1A1CYP1A2
SCHEMBL8036312 0.84 PPARG (0.54) PPARGMAPTMAPK1ALDH1A1MEN1
SCHEMBL8039661 0.83 MAPT (0.50) PPARGMAPTMAPK1ALDH1A1RXFP1
SCHEMBL8034144 0.82 MAPT (0.66) PPARGMAPTMAPK1MEN1KMT2A
SCHEMBL4536851 0.82 MAPT (0.54) PPARGMAPTMAPK1ALDH1A1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083526-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2009-07-09 WO disclosed
WO-2009083526-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2009-07-09 WO disclosed