Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16587068 | 0.83 | CLK1 (0.46) | PARP1CNR1 | |
| SCHEMBL16333800 | 0.80 | ACVR1 (0.51) | HTR6PRKCI | |
| SCHEMBL23518636 | 0.80 | ACVR1 (0.51) | HTR6PRKCI | |
| SCHEMBL16333798 | 0.80 | ACVR1 (0.51) | HTR6PRKCI | |
| SCHEMBL30417848 | 0.76 | IDO1 (0.43) | PIK3CDPIK3R2PARP1CNR1 | |
| SCHEMBL30418923 | 0.73 | IDO1 (0.43) | PIK3CDPIK3R2PARP1CNR1 | |
| SCHEMBL30419567 | 0.73 | HSD17B13 (0.47) | PIK3CDPIK3R2PARP1 | |
| SCHEMBL283372 | 0.71 | CRBN (0.64) | — | |
| SCHEMBL16382725 | 0.71 | KDM4E (0.48) | HTR6PRKCIHTR2BPARP1 | |
| SCHEMBL18945874 | 0.71 | CRBN (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635700-B2 | e.g. 3-(5-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE; cytokine (epidermal/fibroblast/endothelial/tumor necrosis growth factors) antagonist; antitumor, antiinflammatory agent, neurodegenerative diseases | CELGENE CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |