Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153504 | 0.93 | PI4KB (0.63) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4528644 | 0.92 | PI4KB (0.62) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8145173 | 0.91 | PI4KB (0.61) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8147726 | 0.90 | PI4KB (0.66) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8150008 | 0.90 | PI4KB (0.60) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13676271 | 0.90 | PI4KB (0.60) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8146999 | 0.90 | PI4KB (0.60) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8150417 | 0.89 | PI4KB (0.59) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4108816 | 0.89 | PDE4A (0.63) | PI4KBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8149993 | 0.88 | PI4KB (0.61) | PI4KBPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232278-B2 | Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C | GILEAD SCIENCES, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | GILEAD SCIENCES, INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | DPYD, TYMP, PNPO | PI4KB 2356/4885PDE4A 1370/4885PDE4B 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.