Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextromethorphan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 7/20 | 0.95 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 6/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.95 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.95 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.95 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.95 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.95 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.95 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.95 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | TSHR | P16473 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextromethorphan SCHEMBL1321395 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Racemethorphan SCHEMBL30052214 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Dextromethorphan SCHEMBL121923 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Racemethorphan SCHEMBL4894005 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Dextromethorphan SCHEMBL29359586 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Levomethorphan SCHEMBL4910539 | 1.00 | CYP2D6 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Dextromethorphan SCHEMBL4882307 | 0.99 | CYP2D6 (0.98) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Dextromethorphan SCHEMBL121924 | 0.99 | CYP3A4 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Levomethorphan SCHEMBL4933845 | 0.99 | CYP3A4 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 | |
| Racemethorphan SCHEMBL6855351 | 0.99 | CYP3A4 (1.00) | CYP2D6LMNAPMP22CYP3A4GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116018131-A | Fast orodispersible tablet with inner cavity | 阿普雷奇亚制药有限责任公司 | 2023-04-25 | — | — | CN | disclosed |
| US-20090028998-A1 | MULTI-REGION CHEWING GUM COMPOSITION INCLUDING SATURATED PARTICULATE POLYOLS | CADBURY ADAMS USA LLC (US) | 2009-01-29 | — | — | US | disclosed |
| US-5672358-A | STABLE OIL IN WATER EMULSIONS COMPRISING WAX, WATER, ACTIVE MATERIAL; SUSTAINED RELEASING THE DRUG | ASCENT PHARMACEUTICALS, INC. (US) | 1997-09-30 | — | — | US | disclosed |