SCHEMBL4533542

SCHEMBL4533542

Cc1cnc(CN(Cc2ccc(CNC(=O)CCc3ccccc3)cc2CO)[C@@H]2CCCc3cccnc32)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 20/20 0.52
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12935723 1.00 CXCR4 (0.52) CXCR4KCNH2
SCHEMBL2083959 1.00 CXCR4 (0.52) CXCR4KCNH2
SCHEMBL2084892 0.93 CXCR4 (0.53) CXCR4KCNH2
SCHEMBL12935745 0.93 CXCR4 (0.53) CXCR4KCNH2
SCHEMBL12935744 0.92 CXCR4 (0.54) CXCR4
SCHEMBL2082678 0.92 CXCR4 (0.54) CXCR4
SCHEMBL12935733 0.92 CXCR4 (0.54) CXCR4KCNH2
SCHEMBL2085469 0.92 CXCR4 (0.54) CXCR4KCNH2
SCHEMBL2084096 0.87 CXCR4 (0.54) CXCR4KCNH2
SCHEMBL12935688 0.87 CXCR4 (0.54) CXCR4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613613-A4 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2009-03-25 EP disclosed
EP-1613613-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-01-11 EP disclosed
WO-2004091518-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2004-10-28 WO disclosed