Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11425652 | 0.93 | SMN1; SMN2 (0.65) | SMN1; SMN2F10GAAMAPTHPGD | |
| SCHEMBL15259124 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2F10CA2HDAC1HDAC2 | |
| SCHEMBL39896 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2F10GAAMAPTHPGD | |
| SCHEMBL3650164 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK14HPGDHDAC3 | |
| SCHEMBL40224 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2GAAMAPTHPGDALDH1A1 | |
| SCHEMBL13593317 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTHPGDALDH1A1KMT2A | |
| SCHEMBL3499586 | 0.82 | SMN1; SMN2 (0.83) | SMN1; SMN2GAAHPGDNPC1RAB9A | |
| SCHEMBL8544019 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2CA2HDAC3HDAC4HDAC1 | |
| SCHEMBL21142116 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2F10GAAMAPTCA2 | |
| SCHEMBL15071686 | 0.81 | GAA (0.69) | SMN1; SMN2GAAMAPTHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590965-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006474-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |