Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543946 | 0.91 | HRH4 (0.66) | HRH4 | |
| SCHEMBL4537534 | 0.85 | HRH4 (0.50) | HRH4 | |
| SCHEMBL2909049 | 0.80 | HRH4 (0.83) | HRH4 | |
| SCHEMBL4543952 | 0.76 | HRH4 (0.57) | HRH4 | |
| SCHEMBL605260 | 0.73 | HRH4 (0.82) | HRH4 | |
| SCHEMBL2906292 | 0.73 | HRH4 (0.81) | HRH4 | |
| SCHEMBL3950565 | 0.72 | HRH4 (0.54) | HRH4 | |
| SCHEMBL603807 | 0.72 | HRH4 (1.00) | HRH4 | |
| SCHEMBL2910187 | 0.72 | HRH4 (1.00) | HRH4 | |
| SCHEMBL603980 | 0.72 | HRH4 (0.77) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007752-A4 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-22 | — | — | EP | disclosed |
| EP-2007752-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007117399-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | disclosed |