Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542493 | 0.94 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4542179 | 0.90 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4542500 | 0.85 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL13707559 | 0.85 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4542720 | 0.81 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4543827 | 0.81 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4542470 | 0.81 | MAPT (0.66) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4543628 | 0.81 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4539883 | 0.80 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4540256 | 0.80 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |