Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | DHODH | Q02127 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290844 | 0.91 | PDE5A (1.00) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL6068214 | 0.87 | PDE5A (0.88) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29832145 | 0.87 | PDE5A (0.91) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL290788 | 0.87 | PDE5A (0.91) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL291630 | 0.86 | PDE5A (0.89) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2681053 | 0.85 | PDE5A (0.88) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL290610 | 0.84 | PDE5A (0.86) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL291314 | 0.84 | PDE5A (0.86) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2681060 | 0.84 | PDE5A (0.86) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL291112 | 0.84 | PDE5A (0.86) | PDE5AALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846805-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013176877-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | OMEROS CORPORATION (US) | 2013-11-28 | — | — | WO | disclosed |
| EP-2640395-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012064667-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | OMEROS CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |