Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 10/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242203 | 0.85 | SCD (0.52) | MEN1NPC1RAB9AKMT2ASCD | |
| SCHEMBL242637 | 0.79 | KMT2A (0.51) | MEN1NPC1RAB9AKMT2ASCD | |
| SCHEMBL244939 | 0.74 | SCD (0.77) | SCD | |
| SCHEMBL245185 | 0.70 | SCD (0.77) | KMT2ASCDPIK3CDPIK3CBSMN1; SMN2 | |
| SCHEMBL243706 | 0.68 | SCD (0.61) | NPC1SCDPIK3CDPIK3CBSMN1; SMN2 | |
| SCHEMBL610584 | 0.68 | NPC1 (1.00) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL1909601 | 0.68 | NPC1 (0.58) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL243883 | 0.68 | SCD (0.53) | SCDPIK3CDPIK3CBSMN1; SMN2 | |
| SCHEMBL16702679 | 0.67 | SMN1; SMN2 (0.64) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL16404871 | 0.67 | PIK3CD (0.40) | NPC1RAB9APIK3CDPIK3CBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |