Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.68 |
| ▸ | CA12 | O43570 | 2/20 | 0.68 |
| ▸ | F13A1 | P00488 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | CA4 | P22748 | 2/20 | 0.68 |
| ▸ | CA6 | P23280 | 2/20 | 0.68 |
| ▸ | CA5A | P35218 | 2/20 | 0.68 |
| ▸ | THPO | P40225 | 2/20 | 0.68 |
| ▸ | CA7 | P43166 | 2/20 | 0.68 |
| ▸ | CA9 | Q16790 | 2/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.68 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.68 |
| ▸ | CASP2 | P42575 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522294 | 0.97 | TSHR (0.72) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL4474440 | 0.97 | TSHR (0.72) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL4000111 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL11881064 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL1372582 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL11882005 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL9807857 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL2166878 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL22580330 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 | |
| SCHEMBL962833 | 0.95 | TSHR (0.68) | TSHRCA12F13A1CA2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868611-A4 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2009-05-27 | — | — | EP | disclosed |
| EP-1868611-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006104915-A2 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LIMITED (GB) | 2006-10-05 | — | — | WO | disclosed |