Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543995 | 0.92 | MEN1 (0.54) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4544090 | 0.91 | MEN1 (0.68) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4541717 | 0.91 | MEN1 (0.56) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4536923 | 0.89 | PPARG (0.49) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4543112 | 0.84 | MEN1 (0.66) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4542935 | 0.84 | PPARG (0.49) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4543824 | 0.83 | MEN1 (0.48) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4542997 | 0.82 | MEN1 (0.49) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4542409 | 0.82 | MEN1 (0.70) | PPARGMEN1KMT2ANR2E3NCOR2 | |
| SCHEMBL4542797 | 0.82 | PTGER4 (0.52) | PPARGMEN1KMT2ANR2E3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |