Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | TYMS | P04818 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635547 | 0.86 | PIK3CG (0.48) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL4636003 | 0.86 | PIK3CA (0.56) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL4847541 | 0.78 | PIK3CA (0.52) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL27901625 | 0.77 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL4466147 | 0.77 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL27919341 | 0.76 | PIK3CA (0.54) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL27919185 | 0.75 | PIK3CA (0.59) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL27901575 | 0.75 | PIK3CA (0.51) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL27901724 | 0.75 | PIK3CA (0.58) | PIK3CAPIK3CGPIK3CDPIK3CBTYMS | |
| SCHEMBL189083 | 0.75 | PIK3CG (0.77) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-1931645-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Exelixis, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044729-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |