Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.60 |
| ▸ | HTR1B | P28222 | 12/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875206 | 0.89 | HTR1D (0.60) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL252679 | 0.81 | HTR1D (0.60) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL8915192 | 0.80 | CYP1A2 (0.68) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL8416068 | 0.76 | HTR1D (0.62) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL3260325 | 0.75 | HTR1D (0.59) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL3260327 | 0.75 | HTR1D (0.59) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL68753 | 0.75 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| Naratriptan SCHEMBL29403931 | 0.75 | HTR1D (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL3546728 | 0.75 | CYP1A2 (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 | |
| SCHEMBL30908918 | 0.75 | CYP1A2 (1.00) | HTR1DHTR1BHTR1ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118753-A2 | PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE | USV LIMITED (IN) | 2009-10-01 | — | — | WO | claimed |