Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 14/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156938 | 0.79 | BRD4 (0.50) | MAPTEGLN1VEGFALMNA | |
| SCHEMBL4540682 | 0.77 | PDPK1 (0.45) | MAPTTHRBEGLN1VEGFAPDPK1 | |
| SCHEMBL2621619 | 0.76 | SMN1; SMN2 (0.53) | MAPTPDPK1LMNATP53 | |
| SCHEMBL18302940 | 0.75 | SMN1; SMN2 (0.64) | PDPK1 | |
| SCHEMBL3348497 | 0.75 | SMN1; SMN2 (0.52) | PDPK1 | |
| SCHEMBL14307762 | 0.75 | PDPK1 (0.49) | MAPTPDPK1LMNATP53 | |
| SCHEMBL13306807 | 0.75 | PDPK1 (0.54) | MAPTPDPK1LMNA | |
| SCHEMBL14309131 | 0.72 | PDPK1 (0.41) | MAPTTHRBEGLN1VEGFAPDPK1 | |
| SCHEMBL13306800 | 0.72 | MAPT (0.56) | MAPTPDPK1 | |
| SCHEMBL9359813 | 0.72 | MAPT (0.55) | MAPTTHRBEGLN1VEGFALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-B1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |