Minocycline

SCHEMBL4540732

CN(C)c1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O.CN(C)c1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Minocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	TDP1	Q9NUW8	9/20	0.70

▸	KDM4E	B2RXH2	6/20	0.70

▸	USP2	O75604	4/20	0.70

▸	HIF1A	Q16665	3/20	0.70

▸	PTGS1	P23219	2/20	0.70

▸	GRK6	P43250	1/20	0.70

▸	ABCB11	O95342	1/20	0.70

▸	ALB	P02768	1/20	0.70

▸	MAPT	P10636	6/20	0.69

▸	HPGD	P15428	2/20	0.69

▸	CYP3A4	P08684	2/20	0.69

▸	RECQL	P46063	2/20	0.69

▸	HSD17B10	Q99714	4/20	0.61

▸	THPO	P40225	1/20	0.61

▸	KMT2A	Q03164	7/20	0.60

▸	LMNA	P02545	3/20	0.60

▸	BLM	P54132	1/20	0.60

▸	NR1I2	O75469	3/20	0.48

▸	ADORA3	P0DMS8	2/20	0.48

▸	CHRM1	P11229	2/20	0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Minocycline SCHEMBL4960131	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL13320224	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL4042	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL11911315	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL12356688	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL18531248	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL22171064	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL20716523	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL21931671	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1
Minocycline SCHEMBL1820770	1.00	TDP1 (0.70)	TDP1KDM4EUSP2HIF1APTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2637713-A1	ANCHORAGE DEVICES COMPRISING AN ACTIVE PHARMACEUTICAL INGREDIENT	Tyrx, Inc. (US)	2013-09-18	—	—	EP	disclosed
WO-2012064963-A1	ANCHORAGE DEVICES COMPRISING AN ACTIVE PHARMACEUTICAL INGREDIENT	TYRX, INC. (US)	2012-05-18	—	—	WO	disclosed