Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319384 | 1.00 | GRM5 (0.67) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4538662 | 1.00 | GRM5 (0.67) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4539141 | 1.00 | GRM5 (0.67) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4536917 | 1.00 | GRM5 (0.67) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4543530 | 0.87 | GRM5 (0.60) | GRM5 | |
| SCHEMBL5021757 | 0.87 | GRM5 (0.77) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5021739 | 0.86 | GRM5 (0.69) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4537609 | 0.85 | GRM5 (0.62) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5021547 | 0.84 | GRM5 (0.66) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5021180 | 0.84 | GRM5 (0.73) | GRM5KMT2ACYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638022-A1 | OXAZOLIDINONES AS MODULATORS OF MGLUR5 | Bristol-Myers Squibb Company (US) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064603-A1 | OXAZOLIDINONES AS MODULATORS OF MGLUR5 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-18 | — | — | WO | disclosed |