Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BMX | P51813 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538892 | 0.69 | NR3C2 (1.00) | NR3C2SCN10A | |
| SCHEMBL4543080 | 0.68 | NR3C2 (0.65) | NR3C2PROKR1SCN10A | |
| SCHEMBL4542115 | 0.67 | NR3C2 (1.00) | NR3C2MAPK14 | |
| SCHEMBL4537659 | 0.66 | NR3C2 (0.61) | NR3C2PROKR1 | |
| SCHEMBL4538602 | 0.63 | MAPK14 (0.66) | NR3C2MAPK14 | |
| SCHEMBL6984697 | 0.63 | MAPK14 (0.69) | NR3C2MAPK14 | |
| SCHEMBL4129691 | 0.62 | NR3C2 (0.52) | NR3C2 | |
| SCHEMBL1387318 | 0.61 | MAPK14 (0.66) | NR3C2MAPK14 | |
| SCHEMBL4537373 | 0.61 | MAPK14 (0.66) | NR3C2MAPK14 | |
| SCHEMBL6963115 | 0.60 | NR3C2 (0.48) | NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638012-A1 | PYRIDYL UREAS AS MINERALOCORTICOID RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064631-A1 | PYRIDYL UREAS AS MINERALOCORTICOID RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-18 | — | — | WO | disclosed |