SCHEMBL454264

SCHEMBL454264

Nc1ccn([C@H]2CC[C@@H](COP(=O)(O)O)O2)c(=O)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.55
POLB P06746 1/20 0.55
LMNA P02545 3/20 0.48
PDE3A Q14432 3/20 0.48
CACNA1F O60840 2/20 0.48
ALB P02768 2/20 0.48
MAPT P10636 2/20 0.48
CACNA1D Q01668 2/20 0.48
CACNA1S Q13698 2/20 0.48
CACNA1C Q13936 2/20 0.48
P2RY2 P41231 4/20 0.45
P2RY4 P51582 3/20 0.45
P2RY6 Q15077 2/20 0.45
ABL1 P00519 1/20 0.44
RIN1 Q13671 1/20 0.44
POLA1 P09884 1/20 0.43
ST6GAL1 P15907 2/20 0.42
THRB P10828 1/20 0.42
MTOR P42345 1/20 0.42
MDM2 Q00987 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23157216 1.00 POLG (0.55) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL23157013 1.00 POLG (0.55) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL21895844 1.00 POLG (0.55) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL543711 0.93 POLG (0.49) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL543438 0.91 POLG (0.67) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL21626043 0.91 POLG (0.51) POLGPOLBLMNAPDE3ACACNA1F
SCHEMBL6913592 0.90 POLG (0.49) POLGPOLBLMNAPDE3ACACNA1F
Ddctp SCHEMBL16807754 0.90 POLG (0.70) POLGPOLBLMNAPDE3ACACNA1F
Ddctp SCHEMBL18840498 0.90 POLG (0.70) POLGPOLBLMNAPDE3ACACNA1F
Ddctp SCHEMBL30586989 0.90 POLG (0.70) POLGPOLBLMNAPDE3ACACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014031954-A1 HOMOPOLYMER MEDIATED NUCLEIC ACID AMPLIFICATION TUFTS UNIVERSITY (US) 2014-02-27 WO claimed
US-6498036-B1 Methods of targeting a chromosomal gene sequence in a eukaryotic cell TRUSTEES OF AMHERST COLLEGE 2002-12-24 US claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
WO-2025059808-A1 METHOD AND KIT FOR HIGH-THROUGHPUT TAGGING OF CELL NUCLEIC ACID MOLECULES 中国科学院北京基因组研究所(国家生物信息中心) 2025-03-27 WO disclosed
CN-118647729-A Methods and kits for high throughput labeling of cellular nucleic acid molecules 中国科学院北京基因组研究所(国家生物信息中心) 2024-09-13 CN disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed
CN-118005706-A Preparation method of 2',3' -dideoxynucleotide 天津奥利芙生物技术有限公司 2024-05-10 CN disclosed
WO-2024073568-A2 EVOLUTION OF FLUOROGENIC SENSORS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2024-04-04 WO disclosed
EP-3681504-B1 METHODS OF DETECTION USING X-RAY FLUORESCENCE ICAGEN INC (US) 2023-08-23 EP disclosed
US-11573224-B2 Methods of detection using X-ray fluorescence ICAGEN, LLC (US) 2023-02-07 US disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
WO-1994009003-A1 SAPPHYRIN DERIVATIVES, CONJUGATES AND POLYMERS THEREOF AND EXPANDED PORPHYRIN CHROMATOGRAPHIC SUPPORTS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-04-28 WO disclosed
US-5223263-A Viricide complex; aids therapy VICAL, INC. (US) 1993-06-29 US disclosed
WO-1992022306-A1 TRANSFORMED ERYTHROCYTES, PROCESS FOR PREPARING THE SAME, AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS COMMUNAUTE ECONOMIQUE EUROPEENNE (CEE) (LU) 1992-12-23 WO disclosed
EP-0517986-A1 Transformed erythrocytes, process for preparing the same, and their use in pharmaceutical compositions COMMUNAUTE ECONOMIQUE EUROPEENNE (CEE) (LU) 1992-12-16 EP disclosed
WO-1990000555-A1 LIPID DERIVATIVES OF ANTIVIRAL NUCLEOSIDES, LIPOSOMAL INCORPORATION AND METHOD OF USE VICAL, INC. (US) 1990-01-25 WO disclosed
EP-0350287-A2 Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use NeXstar Pharmaceuticals, Inc. (US) 1990-01-10 EP disclosed
WO-1988007854-A1 NEW ANTI-RETROVIRAL AGENTS AND DELIVERY SYSTEM UNITED STATES OF AMERICA, REPRESENTED BY THE UNITE (US) 1988-10-20 WO disclosed
EP-0286418-A1 Anti-retroviral agents and delivery systems for the same THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1988-10-12 EP disclosed
EP-0284405-A2 Anti-viral compounds, dosage forms and methods BAKER NORTON PHARMACEUTICALS, INC. (US) 1988-09-28 EP disclosed