Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542967 | 1.00 | MAPT (0.72) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4544081 | 1.00 | MAPT (0.72) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4537558 | 0.88 | MAPT (0.56) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4543793 | 0.87 | CYP1A2 (0.59) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4540191 | 0.82 | MAPT (0.82) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4540168 | 0.81 | MAPT (0.74) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4539294 | 0.80 | MAPT (0.65) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4542171 | 0.78 | MEN1 (0.73) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4542879 | 0.78 | MAPT (0.65) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4540292 | 0.77 | MAPT (0.64) | MAPTNPSR1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |