Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454599 | 1.00 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL469223 | 1.00 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL13186852 | 0.91 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| Iodide SCHEMBL453051 | 0.90 | NPC1L1 (0.49) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| Iodide SCHEMBL453050 | 0.90 | NPC1L1 (0.49) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL469331 | 0.89 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL451950 | 0.89 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL451949 | 0.89 | NPC1L1 (0.50) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL10070770 | 0.89 | NPC1L1 (0.53) | NPC1L1CYP3A4CNR1ABCB11LMNA | |
| SCHEMBL454832 | 0.89 | NPC1L1 (0.53) | NPC1L1CYP3A4CNR1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212175-B2 | Pharmaceutical hypocholesterolemic compositions | LIPIDEON BIOTECHNOLOGY AG (CH) | 2015-12-15 | — | — | US | disclosed |
| US-20120065168-A1 | Pharmaceutical Hypocholesterolemic Compositions | LIPIDEON BIOTECHNOLOGY AG (CH) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065168-A1 | Pharmaceutical Hypocholesterolemic Compositions | CYP46A1, DHCR7, HMGCR | NPC1L1 5/4885CYP3A4 546/4885CNR1 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.