Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848239 | 0.91 | BRAF (0.59) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1845541 | 0.88 | BRAF (0.59) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1846987 | 0.88 | BRAF (0.71) | BRAFCYP2D6CYP2C9MAPK14 | |
| SCHEMBL1847994 | 0.87 | BRAF (0.60) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1849041 | 0.87 | BRAF (0.58) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1849038 | 0.86 | BRAF (0.57) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1851198 | 0.86 | BRAF (0.61) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL1853242 | 0.86 | BRAF (0.59) | BRAFCYP2D6CYP2C9MAPK14KDR | |
| SCHEMBL12684807 | 0.84 | BRAF (0.68) | BRAFCYP2D6CYP2C9MAPK14LYN | |
| SCHEMBL1850458 | 0.83 | MAPK14 (0.56) | BRAFCYP2D6CYP2C9MAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324008-B1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-05-09 | — | — | EP | disclosed |
| WO-2010010154-A1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-01-28 | — | — | WO | disclosed |