Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.64 |
| ▸ | RAF1 | P04049 | 13/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 4/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14274791 | 0.94 | BRAF (0.63) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2677623 | 0.91 | BRAF (0.63) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL4366536 | 0.88 | BRAF (0.67) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2676841 | 0.85 | BRAF (0.69) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2677737 | 0.85 | BRAF (0.71) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL4360717 | 0.85 | BRAF (0.70) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2677520 | 0.84 | BRAF (0.66) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2678246 | 0.83 | BRAF (0.61) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2676968 | 0.82 | BRAF (0.65) | BRAFRAF1KCNH2CSF1RPDGFRB | |
| SCHEMBL2676248 | 0.82 | BRAF (0.66) | BRAFRAF1KCNH2CSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173689-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |
| US-8173689-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |