Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 17/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.58 |
| ▸ | KIT | P10721 | 7/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.58 |
| ▸ | FLT3 | P36888 | 7/20 | 0.58 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676708 | 0.92 | CSF1R (0.60) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2675951 | 0.92 | CSF1R (0.62) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676241 | 0.91 | CSF1R (0.58) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2678035 | 0.91 | CSF1R (0.61) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2675471 | 0.90 | CSF1R (0.60) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2677425 | 0.90 | CSF1R (0.58) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676898 | 0.90 | CSF1R (0.59) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2677966 | 0.89 | CSF1R (0.58) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2677721 | 0.89 | CSF1R (0.57) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2677651 | 0.89 | CSF1R (0.57) | CSF1RPDGFRBKITPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173689-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |
| US-8173689-B2 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |