Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.60 |
| ▸ | KCNJ1 | P48048 | 14/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733227 | 1.00 | KCNH2 (0.60) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549666 | 0.91 | KCNH2 (0.56) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196827 | 0.90 | KCNH2 (0.58) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549589 | 0.90 | KCNH2 (0.58) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549557 | 0.89 | KCNJ1 (0.75) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549545 | 0.85 | KCNH2 (0.58) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549541 | 0.82 | KCNH2 (0.77) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL14785986 | 0.81 | KCNH2 (0.77) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549667 | 0.79 | KCNH2 (0.72) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196973 | 0.79 | KCNJ1 (0.51) | KCNH2KCNJ1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |