Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 15/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196934 | 0.75 | KCNJ1 (0.63) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15196712 | 0.75 | KCNJ1 (0.79) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL2731338 | 0.72 | KCNH2 (0.76) | KCNJ1KCNH2SIGMAR1 | |
| SCHEMBL15196767 | 0.70 | KCNJ1 (0.75) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15196781 | 0.70 | KCNH2 (0.61) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL2731436 | 0.70 | KCNJ1 (1.00) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549576 | 0.69 | KCNH2 (0.81) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL9731780 | 0.69 | KCNH2 (0.71) | KCNJ1KCNH2 | |
| SCHEMBL15191673 | 0.67 | KCNJ1 (0.91) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL297835 | 0.66 | KCNJ1 (0.64) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |