Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19286909 | 0.88 | STK17B (0.48) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL18495142 | 0.85 | STK17B (0.47) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL20584280 | 0.85 | STK17B (0.47) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL4549891 | 0.85 | STK17B (0.47) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL2722937 | 0.85 | STK17B (0.47) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL2722934 | 0.85 | STK17B (0.47) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL4549828 | 0.85 | STK17B (0.48) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL10082684 | 0.85 | STK17B (0.48) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL2726114 | 0.84 | STK17B (0.41) | STK17BSTK17ASYKPCSK9AAK1 | |
| SCHEMBL20512302 | 0.84 | STK17B (0.41) | STK17BSTK17ASYKPCSK9AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3118203-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2017-01-18 | — | — | EP | disclosed |
| EP-2632467-B1 | CDK INHIBITORS | G1 THERAPEUTICS INC (US) | 2016-06-22 | — | — | EP | disclosed |
| EP-2955183-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014144740-A2 | HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144326-A1 | TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014144847-A2 | HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION | G1 THERAPEUTICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2012061156-A1 | CDK INHIBITORS | TAVARES FRANCIS X (US) | 2012-05-10 | — | — | WO | disclosed |