SCHEMBL4550312

SCHEMBL4550312

Cc1cc(C(=O)NCc2cnc(OCC(F)(F)F)c(CI)c2)cc(NC(=O)C(C)(C)O)n1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 3/20 0.43
KCNH2 Q12809 1/20 0.35
SCN5A Q14524 1/20 0.35
SCN2A Q99250 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
RIPK1 Q13546 7/20 0.34
EPHX2 P34913 1/20 0.33
MAPT P10636 2/20 0.33
GSK3B P49841 1/20 0.33
PTK2 Q05397 1/20 0.32
CNR2 P34972 2/20 0.31
TACR1 P25103 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
KMT2A Q03164 1/20 0.31
P2RX3 P56373 1/20 0.31
P2RX2 Q9UBL9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2719347 0.93 SCN9A (0.46) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2719110 0.90 SCN9A (0.44) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2715312 0.88 SCN9A (0.52) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2716797 0.83 SCN9A (0.48) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2717853 0.82 SCN9A (0.47) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2714475 0.82 SCN9A (0.58) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2717159 0.82 SCN9A (0.44) SCN9AKCNH2RIPK1MAPTGSK3B
SCHEMBL2717939 0.82 SCN9A (0.41) SCN9AKCNH2SCN5ASCN2ASCN10A
SCHEMBL2716387 0.81 SCN9A (0.41) SCN9ARIPK1MAPTALDH1A1KMT2A
SCHEMBL2716334 0.80 SCN9A (0.46) SCN9AKCNH2SCN5ASCN2ASCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012053186-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2012-04-26 WO disclosed