Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715032 | 0.86 | GSK3B (0.48) | MAPTGSK3BSCN9AACACBPDE2A | |
| SCHEMBL2718235 | 0.85 | PDE2A (0.52) | MAPTGSK3BSCN9AACACBTRPV1 | |
| SCHEMBL2718234 | 0.85 | PDE2A (0.52) | MAPTGSK3BSCN9AACACBTRPV1 | |
| SCHEMBL2715785 | 0.84 | MAPK1 (0.49) | MAPTGSK3BNTRK1MAPK1MEN1 | |
| SCHEMBL18266729 | 0.80 | MAPT (0.47) | MAPTGSK3BSCN9AACACBMAPK1 | |
| SCHEMBL15349989 | 0.79 | TRPV1 (0.49) | MAPTGSK3BTRPV1PDE2AMAPK1 | |
| SCHEMBL18266507 | 0.79 | MAPT (0.49) | MAPTGSK3BSCN9AACACBPDE2A | |
| SCHEMBL4550821 | 0.78 | GSK3B (0.59) | MAPTGSK3BSCN9AACACBMAPK1 | |
| SCHEMBL2714555 | 0.78 | ACACB (0.48) | GSK3BACACBPDE2ANTRK1MAPK1 | |
| SCHEMBL16234568 | 0.78 | SCN9A (0.50) | MAPTGSK3BSCN9AACACBWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053186-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-04-26 | — | — | WO | disclosed |