Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2716247 | 0.98 | CSNK2A1 (0.60) | CSNK2A1MRGPRX4HTR2AHTR2CHTR2B | |
| SCHEMBL18266448 | 0.88 | CSNK2A1 (0.61) | CSNK2A1MRGPRX4GLASMN1; SMN2LMNA | |
| SCHEMBL2714429 | 0.85 | TTR (0.43) | CSNK2A1MRGPRX4HTR2AHTR2CHTR2B | |
| SCHEMBL2716370 | 0.83 | NPC1 (0.52) | CSNK2A1MRGPRX4HTR2AHTR2CHTR2B | |
| SCHEMBL4550404 | 0.81 | CSNK2A1 (0.39) | CSNK2A1HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL17159703 | 0.81 | SMN1; SMN2 (0.41) | CSNK2A1MRGPRX4HTR2AHTR2CHTR2B | |
| SCHEMBL4550407 | 0.80 | CSNK2A1 (0.41) | CSNK2A1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL2715847 | 0.80 | HTR2A (0.41) | CSNK2A1HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4689675 | 0.80 | CSNK2A1 (0.55) | CSNK2A1MRGPRX4GLASMN1; SMN2LMNA | |
| SCHEMBL4688982 | 0.80 | CSNK2A1 (0.55) | CSNK2A1MRGPRX4GLASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |
| US-20140336377-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2014-11-13 | — | — | US | disclosed |
| US-20140336377-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2014-11-13 | — | — | US | disclosed |
| WO-2012053186-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336377-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN2B, SCN1B, SCN2A | CSNK2A1 2688/4885MRGPRX4 950/4885HTR2A 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.